Community Impact in Action

SDGs

Exploring for hypoxia response regulative components derived from fishes caught in Shizuoka prefecture and disease control

In a joint study with the Shizuoka University, the Shizuoka Prefectural Fisheries and Marine Technology Research Institute focused on Substance A, based on the screening results of specific fish-derived substances. First, in vitro experiments confirmed that Substance A has a HIF-inhibiting effect. Next, in experiments using laser-induced choroidal neovascularization (CNV) mice, a model for age-related macular degeneration, it was found that Substance A reduces the area of CNV. Furthermore, qPCR analysis revealed that Substance A suppresses the expression of inflammatory factors such as IL-6. These results suggest that Substance A has the potential to be a new therapeutic agent for age-related macular degeneration.

Applicable regions

Shizuoka prefecture

Implementation period

October, 2019 - present

Community and Regional Affairs category

• Regional collaboration as research targets and implementation sites/research that aims to popularize region-specific issues

Related websites

Marine Open Innovation (MaOI) project

Press release regarding the collaborative study

Related agreements, etc.

Seeds creation research work centered on marine biotechnology

Cooperating institutions, etc.

Shizuoka Prefectural Research Institute of fishery and Marine
Fuculty of Agriculture, Shizuoka University

Campus

Shinanomachi

Person in charge

Toshihide Kurihara, MD/PhD

Inquiries

kurihara.z8@keio.jp

Other partnerships and collaborations