Access Inquiries Search Japanese English

home | Community Partnerships/Social Contributions

Organizational System for Community and Regional Affairs Organizational System for Community and Regional


Exploring for hypoxia response regulative components derived from fishes caught in Shizuoka prefecture and disease control

In recent years, it has become evident that hypoxia-inducible factor (HIF) plays an important role in retinal degenerative diseases that cause blindness. We selected six species of fish which contain extracts with HIF inhibitory effects from among Shizuoka Prefecture fish species collected at the Shizuoka Prefectural Fisheries and Marine Technology Research Institute, and continued the fractionation, purification and structural elucidation of the active substances at the Faculty of Agriculture, Shizuoka University. In addition, in vitro screening was conducted at the Keio University School of Medicine’s Department of Ophthalmology, Laboratory of Photobiology. The active ingredients obtained were administered to animal disease models and their efficacy was confirmed.

Applicable regions

Shizuoka prefecture

Implementation period

October, 2019 - present

Community and Regional Affairs category

  • Regional collaboration as research targets and implementation sites/research that aims to popularize region-specific issues

Related agreements, etc.

Seeds creation research work centered on marine biotechnology

Cooperating institutions, etc.

Shizuoka Prefectural Research Institute of fishery and Marine
Fuculty of Agriculture, Shizuoka University



Person in charge

Toshihide Kurihara, MD/PhD